2-Guanidinobezimidazole
Product Specifications
CAS Number
5418-95-1
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 ?M for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB) .
Smiles
N=C(N)NC1=NC=2C=CC=CC2N1
Molecular Formula
C8H9N5
Molecular Weight
175.191
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9320510-01 48 Well
Rat Double-stranded RNA-binding protein Staufen homolog 2, STAU2 ELISA Kit
Ask
View Details MBS9320510-02 96 Well
Rat Double-stranded RNA-binding protein Staufen homolog 2, STAU2 ELISA Kit
Ask
View Details 
MBS9320510-03 5x 96 Well
Rat Double-stranded RNA-binding protein Staufen homolog 2, STAU2 ELISA Kit
Ask
View Details