EGFR-IN-144
Product Specifications
Target
Microtubule Associated|||Interleukin|||Apoptosis|||EGFR|||TNF
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis|||Immunology/Inflammation|||Angiogenesis|||JAK/STAT signaling|||Cytoskeletal Signaling
Bioactivity
EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL) . It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-?, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.
Smiles
CC1=C(N=NN1C2=C(C=C(C=C2)Cl)Cl)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC
Molecular Formula
C20H17Cl2N3O3
Molecular Weight
418.273
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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