HDAC6 degrader-5
Product Specifications
Target
HDAC|||Interleukin|||Apoptosis
Related Pathways
DNA Damage/DNA Repair|||Apoptosis|||Immunology/Inflammation|||Chromatin/Epigenetic
Bioactivity
HDAC6degrader-5 (Compound 6) exhibits inhibitory and degradative activity against HDAC6, with an IC50 of 4.95 nM and a DC50 of 0.96 nM. It suppresses the release of TNF-?, IL-1?, and IL-6, and prevents apoptosis in liver cells. Additionally, HDAC6degrader-5 demonstrates anti-inflammatory properties in a mouse model of APAP-induced liver injury.
Smiles
CCCC1=CC(=NN1CC2=CC=C(C=C2)C(=O)NO)C(=O)NC3=CC=CC=C3
Molecular Formula
C21H22N4O3
Molecular Weight
378.424
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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