DU-14 (PTP1B/TC-PTP PROTAC)
Product Specifications
CAS Number
3053413-58-1
Target
STAT|||PROTACs
Related Pathways
PROTAC|||Stem Cells|||JAK/STAT signaling
Bioactivity
DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-? signaling, promotes T cell activation, and possesses antitumor activity.
Smiles
C([C@@H](NC(CC1=CC(CNC([C@@H](NC([C@H](CC2=CC=C(C(P(=O)(O)O)(F)F)C=C2)NC([C@H](CC3=CC=CC=C3)NC(CC4=CC(OC)=C(O)C=C4)=O)=O)=O)CCCCNC(=O)C5=CC(Br)=C(C)C=C5)=O)=CC=C1)=O)C(C)(C)C)(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6
Molecular Formula
C74H85BrF2N9O14PS
Molecular Weight
1505.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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