DU-14 (PTP1B/TC-PTP PROTAC)

Product Specifications

CAS Number

3053413-58-1

Target

STAT|||PROTACs

Related Pathways

PROTAC|||Stem Cells|||JAK/STAT signaling

Bioactivity

DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-? signaling, promotes T cell activation, and possesses antitumor activity.

Smiles

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