JBJ-07-149
Product Specifications
CAS Number
2140807-58-3
Target
EGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Bioactivity
JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 ?M when used alone, and 0.148 ?M when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].
Smiles
O=C1C2=CC(=CC=C2CN1C(C(=O)NC3=NC=CS3)C=4C=CC=CC4)C=5C=NC(=CC5)N6CCNCC6
Molecular Formula
C28H26N6O2S
Molecular Weight
510.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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