Fibrostat
Product Specifications
Target
HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
Fibrostat (Compound 5n) is a selective HDAC6 inhibitor that exerts antifibrotic effects by hindering HDAC6 activity, with an IC50 value of 63 nM for HDAC6. It exhibits superior selectivity over HDAC1, HDAC3, HDAC5, HDAC8, HDAC10, and HDAC11. Fibrostat effectively reduces the expression of fibrosis markers, fibronectin and collagen 1, in fibroblasts. It shows no toxicity in rat perfused heart and zebrafish larvae studies. Fibrostat holds promise for research on fibrosis-related diseases.
Molecular Formula
C29H32N4O3
Molecular Weight
484.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
QP6024-ec-1mg 1mg
Recombinant Human F-box/ LRR-repeat protein 18 Protein, His-SUMO, E.coli-1mg
Ask
View Details 
F0302 96 Tests
Mitochondrial import Receptor subunit TOM22 homolog (TOMM22) Mouse ELISA Kit
Ask
View Details 
MBS7193586 Inquire
Rabbit anti-Synechococcus elongatus (strain PCC 7942)(Anacystis nidulans R2) rpmJ Polyclonal Antibody
Ask
View Details