WB214
Product Specifications
CAS Number
2640723-72-2
Bioactivity
WB214 is an MDM2 degrader (IC50 = 1.2 nM) . Identified as the most potent antiproliferative agent in various leukemia cell lines, WB214 not only effectively promotes MDM2 degradation but also results in p53 degradation. Further studies demonstrate that WB214 acts as a molecular glue to degrade MDM2. It was ultimately discovered that WB214 efficiently degrades GSPT1, which helps to elucidate its mechanism of cell growth inhibition.
Smiles
O=C(OCC)C=1NC=2C=C(Cl)C=CC2C1C(C(=O)NC(C)(C)C)N(C(=O)CCCCC#CC3=CC=CC=4C(=O)N(CC34)C5C(=O)NC(=O)CC5)CC6=CC(F)=C(F)C(F)=C6
Molecular Formula
C44H43ClF3N5O7
Molecular Weight
846.29
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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