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I194496

Product Specifications

CAS Number

445238-07-3

Target

Annexin A|||Akt|||VEGFR|||FAK|||ERK|||PI3K|||Ras|||Raf|||STAT|||Others

Related Pathways

Cytoskeletal Signaling|||GPCR/G Protein|||MAPK|||Others|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Angiogenesis

Bioactivity

I194496 is an effective inhibitor of cystathionine ?-lyase (CSE) with an IC50 value of 0.79 mM. It inhibits the growth of human TNBC cells by dual targeting the PI3K/Akt and Ras/Raf/ERK pathways. Additionally, I194496 suppresses the metastasis of human TNBC cells by downregulating the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways.

Smiles

O=C(NC1=CC=C(C=C1)S(=O)(=O)NC=2C=CC=CC2OC)C=3C=NN4C3N=C(C=C4C(F)F)C=5C=CC(OC)=CC5

Molecular Formula

C28H23F2N5O5S

Molecular Weight

579.58

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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