Pan-KRAS degrader 1
Product Specifications
CAS Number
2937327-83-6
Target
Ras
Related Pathways
GPCR/G Protein|||MAPK
Bioactivity
Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR) . Additionally, this compound demonstrates antitumor activity.
Smiles
C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C4=NC(=NC=C4)N5[C@@H](C)CNCCC5
Molecular Formula
C22H26N8OS
Molecular Weight
450.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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