SEL120-34A (hydrochloride)
Product Specifications
UNSPSC Description
SEL120-34A hydrochloride is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sel120-34a-hydrochloride.html
Purity
99.98
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC1=C(Br)C(Br)=C2C3=C1N=C(N4CCNCC4)N3CCC2.Cl
References & Citations
[1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8(20):33779-33795.Cell. 2021 Apr 15;184(8):2167-2182.e22.|Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2024 Mar 19;15(1):2198.|Nat Commun. 2019 Oct 18;10(1):4741. |Int J Mol Sci. 2022 Feb 24;23(5):2493.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111388B/SEL120-34A-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111388B/SEL120-34A-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1609452-30-3
Available Sizes
Curated Selection
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