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Recombinant human GRO alpha/CXCL1 protein

CXCL1/GROa is a growth factor for melanoma cells and a chemotaxin for neutrophils. Similar to other alpha chemokines, this protein is potent neutrophil attractant and activator and is also active toward basophils. In addition, CXCL1 protein may be a therapeutic target as well as a diagnostic marker in ovarian cancer. Recombinant CXCL1 protein was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

SCYB1, Neutrophil-activating protein 3, NAP-3, MGSA, Melanoma growth stimulatory activity, Growth-regulated alpha protein, GRO-alpha (1-73), GROA, GRO1 oncogene, GRO1, GRO, FSP, Fibroblast secretory protein, C-X-C motif chemokine ligand 1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by BCA assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

10.1 kDa (94aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

CXCL1, GRO a, Chemokine (C-X-C motif) ligand 1 / Growth-regulated alpha protein, FSP, GRO1, GROA, MGSA, NAP-3, SCYB1, Chemokine (C-X-C motif) ligand 1, Growth-regulated alpha protein, Chemokine (C-X-C motif) ligand 1 / Growth-regulated alpha protein, CXCL1, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity alpha), GRO1 oncogene (melanoma growth stimulating activity alpha), fibroblast secretory protein, SCYB1, MGSA-a, CXC0901-10 µg, CXC0901-20 µg, CXC0901-50 µg, CXC0901-100 µg, CXC0901-250 µg, CXC0901-500 µg, CXC0901-1 mg, CXC0901-10, CXC0901-20, CXC0901-50, CXC0901-100, CXC0901-250, CXC0901-500, CXC0901-1

References & Citations

Kawanishi H, et al. (2008) Clin Cancer Res., 2579-87; ; Yang HT, et al. (2008) Cell Signal, 375-80; ; Yang G, et al. (2006) Proc Natl Acad Sci u S A, 16472-7;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_001502

Uniprot Accession Number

P09341

Species

Human

AA Sequence

MASVATELRC QCLQTLQGIH PKNIQSVNVK SPGPHCAQTE VIATLKNGRK ACLNPASPIV KKIIEKMLNS DKSN

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