Recombinant mouse Pentraxin 2/PTX2 protein
Pentraxin2, also known as serum amyloid P-component, is a secreted serum glycoprotein that belongs to the pentraxins family. This family binds calcium-dependent lectin-like manner and is characterized distinctive flattened Beta-jellyroll structure similar to the legume lectins. This protein is a non-fibrillar component, it can interact with DNA and histones. It regulates the solubility of amyloid fibrils and protects them from degradation by proteolytic enzymes and phagocytic cells. This protein is the major acute-phase protein and expression of it is dependent on complement activation, IL-6 and/or IL-1 beta. Recombinant mouse Pentraxin2 protein, fused to His-tag at C-terminus, was expressed in HEK293 and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Serum amyloid P-component, SAP, Apcs, Sap
Expression System
HEK293
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
24.6 kDa (210aa)
Additionnal Information
References & Citations
Xi D., et al, (2015) Int J Cardiol. 187:20-26.; ; Muczynski V., et al, (2017) Blood. 101 (9) : 129 (17) :2443-2454.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_035448
Uniprot Accession Number
P12246
Species
Mouse
N Terminal Sequence
Gln21
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