Recombinant human CD1d protein
CD1D, also known as antigen-presenting glycoprotein CD1d isoform 1, is a transmembrane glycoprotein in the CD1 family of glycolipid antigen-presenting MHC-like molecules. CD1d-presented lipid antigens activate a special class of T cells, known as natural killer T (NKT) cells, through the interaction with the T-cell receptor present on NKT membranes. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and interleukin 4 production. Recombinant human CD1D protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Antigen-presenting glycoprotein CD1d isoform 1, CD1D, CD1A, R3, R3G1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.9 kDa (290aa)
Additionnal Information
References & Citations
Broxmeyer HE., et al, (2012) Blood. 119:5731-5741.; ; Huh JY., et al, (2017) Diabetes. 66:835-847.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001757.1
Uniprot Accession Number
P15813
Species
Human
N Terminal Sequence
Glu20
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