Recombinant rat IL-33 protein
Il33 also known as Interleukin-33. Il33 induces production of large amounts of IL5 and IL13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. Il33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress. Recombinant rat Il33, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-33
Expression System
E.coli
Antigen Species
Rat
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
19.8 kDa (179aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Cayrol C., et al. (2014) Current Opinion in Immunology. 31:31-37. ; ; Pomeshchik Y., et al. (2015) Brain Behavior Immunity. 44:68-81
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001014188
Uniprot Accession Number
Q66H70
Species
Rat
AA Sequence
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