Recombinant human SPRED1 protein
SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. This protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS) . Recombinant human SPRED1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Sprouty-related EVH1 domain-containing protein 1, Sprouty-related, EVH1 domain-containing protein 1, hSpred1, NFLS, spred-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
52.9 kDa (467aa)
Additionnal Information
References & Citations
Nonami A., et al. (2005) Genes Cells 10:887-895.; ; King J.A.J., et al. (2005) Biochem. J. 388:445-454.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_689807
Uniprot Accession Number
Q7Z699
Species
Human
AA Sequence
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