Recombinant human MAP1/MOAP1 protein

Modulator of apoptosis 1, also known as MOAP1, belongs to the PNMA family and contains one BH3-like domain and one RASSF1-binding domain. It is required for death receptor-dependent apoptosis. MOAP1 homodimerizes and associates with the proapoptotic Bax and the prosurvival Bcl-2 and Bcl-X (L) of the Bcl-2 family in vitro and in vivo in mammalian cells. These data suggest that MOAP1 mediates apoptosis through a mechanism that involves binding to Bax. Recombinant human MOAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Modulator of apoptosis 1, MAP-1, PNMA4, Paraneoplastic antigen Ma4

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

41.9 kDa (374aa)

Additionnal Information

MOAP1, Modulator of apoptosis 1, MAP-1, PNMA4, ATGP2404-10 µg, ATGP2404-20 µg, ATGP2404-50 µg, ATGP2404-100 µg, ATGP2404-250 µg, ATGP2404-500 µg, ATGP2404-1 mg, ATGP2404-10, ATGP2404-20, ATGP2404-50, ATGP2404-100, ATGP2404-250, ATGP2404-500, ATGP2404-1

References & Citations

Baksh S., et al. (2005) Mol Cell. 18:637-650.; ; Tan K O., et al. (2001) J Biol Chem. 276:2802-2807.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Apoptosis

NCBI Accession Number

NP_071434

Uniprot Accession Number

Q96BY2

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMTLRLLE DWCRGMDMNP RKALLIAGIS QSCSVAEIEE ALQAGLAPLG EYRLLGRMFR RDENRKVALV GLTAETSHAL VPKEIPGKGG IWRVIFKPPD PDNTFLSRLN EFLAGEGMTV GELSRALGHE NGSLDPEQGM IPEMWAPMLA QALEALQPAL QCLKYKKLRV FSGRESPEPG EEEFGRWMFH TTQMIKAWQV PDVEKRRRLL ESLRGPALDV IRVLKINNPL ITVDECLQAL EEVFGVTDNP RELQVKYLTT YQKDEEKLSA YVLRLEPLLQ KLVQRGAIER DAVNQARLDQ VIAGAVHKTI RRELNLPEDG PAPGFLQLLV LIKDYEAAEE EEALLQAILE GNFT