Recombinant human HBG2 protein
Hemoglobin subunit gamma-2, also known as HBG2, belongs to the fetal hemoglobin subunit, which consists of two alpha chains together with two gamma chains. Increased fetal hemoglobin production in adults can ameliorate the clinical severity of sickle cell disease and beta-thalassemia major. Recombinant human HBG2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Hemoglobin subunit gamma-2, TNCY
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
18.5 kDa (170aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Feng L., et al. (2004) Cell. 119:629-640.; ; Liebhaber S A., et al. (1981) Nature.290:26-29.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol,1mM DTT
Scientific Category
Cardiovascular
NCBI Accession Number
NP_000175.1
Uniprot Accession Number
P69892
Species
Human
AA Sequence
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