Recombinant human Complement Factor D protein

CFD, also known as adipsin, is involved in the alternative complement pathway of the complement system where it cleaves factor B. This protein is a member of the trypsin family of peptidases. It is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, it has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. Recombinant human CFD protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Complement factor D, DF, AND, PFD, ADIPSIN

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

26.6 kDa (249aa)

Additionnal Information

Complement Factor D, Complement factor D, DF, AND, PFD, ADIPSIN, ATGP1877-10 µg, ATGP1877-20 µg, ATGP1877-50 µg, ATGP1877-100 µg, ATGP1877-250 µg, ATGP1877-500 µg, ATGP1877-1 mg, ATGP1877-10, ATGP1877-20, ATGP1877-50, ATGP1877-100, ATGP1877-250, ATGP1877-500, ATGP1877-1

References & Citations

Narayana SV. et al. (1994) J Mol Biol. 235:695-708.; ; Ronti T. et al. (2006) Clin Endocrinol (Oxf) . 64:355-365.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Immunology

NCBI Accession Number

NP_001919

Uniprot Accession Number

P00746

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MILGGREAEA HARPYMASVQ LNGAHLCGGV LVAEQWVLSA AHCLEDAADG KVQVLLGAHS LSQPEPSKRL YDVLRAVPHP DSQPDTIDHD LLLLQLSEKA TLGPAVRPLP WQRVDRDVAP GTLCDVAGWG IVNHAGRRPD SLQHVLLPVL DRATCNRRTH HDGAITERLM CAESNRRDSC KGDSGGPLVC GGVLEGVVTS GSRVCGNRKK PGIYTRVASY AAWIDSVLA