Recombinant human DECR1 protein
DECR1 is a mitochondrial protein that exists as a homotetramer and belongs to the family of short-chain dehydrogenases/reductases. It functions as an auxiliary enzyme of beta-oxidation andt participates in the metabolism of unsaturated fatty enoyl-CoA esters. Specifically, DECR1 uses NADP+ to catalyze the reduction of 2, 4-dienoyl-CoA to yield trans-3-enoyl-CoA, which can then be used as an intermediate in the Krebs cycle. Additionally, DECR1 is thought to function as a tumor suppressor, possibly downregulating the expression of Neu and slowing the rate of tumorigenesis. Recombinant human DECR1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
24-dienoyl-CoA reductase mitochondrial, 2,4-dienoyl-CoA reductase, mitochondrial, DECR, NADPH, SDR18C1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.4 kDa (322aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Koivuranta KT., et al. (1994) Biochem J. 304 (3) :787-92. ; ; Roe CR., et al. (1990) J Clin Invest. 85 (5) :1703-7.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
NP_001350
Uniprot Accession Number
Q16698
Species
Human
AA Sequence
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