Recombinant human Calbindin1 protein
Calbindin 1 is a calcium binding protein belonging to the troponin C superfamily. Calbindin is expressed in neural tissues. It plays an essential role in calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to epilepsy, amyotrophic lateral sclerosis, Huntington's disease. Recombinant human Calbindin1 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CAB27, Calbindin D28, D-28K, CALB1, calbindin 1 28kDa, CALB, Calbindin1
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
30 kDa (261aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Heizmann CW., et al. (1988) J Cardiovasc Pharmacol. 5:S30-7.; ; Kaqi u., et al. (1988) Cell Tissue Res. 252 (2) :359-65. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 2mM EDTA
Scientific Category
Neuroscience
NCBI Accession Number
NP_004920
Uniprot Accession Number
P05937
Species
Human
AA Sequence
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