Human MEMO1 antibody
MEMO1 (Mediator of ErbB2-driven cell motility 1) is a 297 amino acid protein. It is thought to relax extracellular chemotactic signals that are targeted at the microtubule cytoskeleton, thereby controlling cell migration. Additionally, MEMO1 is required for breast carcinoma migration, suggesting an important role in tumorigenesis. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity.
Product Specifications
Product Name Alternative
Protein MEMO1, C2orf4, CGI-27, MEMO, NS5ATP7
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human MEMO1 (1-297aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT1E9
Conjugation
Unconjugated
Applications
ELISA, WB, FACS
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
References & Citations
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
Scientific Category
Signal Transduction
NCBI Accession Number
NP_057039
Uniprot Accession Number
Q9Y316
WB Description
FACS Description
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