SCS

SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions[1].

Product Specifications

CAS Number

[3232-36-8]

Product Name Alternative

Salicylidene salicylhydrazide

UNSPSC

12352005

Hazard Statement

H302

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/scs.html

Purity

99.64

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N/N=C/C1=CC=CC=C1O)C2=CC=CC=C2O

Molecular Formula

C14H12N2O3

Molecular Weight

256.26

Precautions

H302

References & Citations

[1]Thompson SA, et al. Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. Br J Pharmacol. 2004 May;142 (1) :97-106.|[2]Rukh L, et al. Efficacy assessment of salicylidene salicylhydrazide in chemotherapy associated peripheral neuropathy. Eur J Pharmacol. 2020 Dec 5;888:173481.