Sonidegib (diphosphate)

Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].

Product Specifications

CAS Number

[1218778-77-8]

Product Name Alternative

Erismodegib (diphosphate) ; LDE225 (diphosphate) ; NVP-LDE225 (diphosphate)

UNSPSC

12352005

Hazard Statement

H360

Target

Smo

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LDE225-Diphosphate.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 0.25 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4.O=P(O)(O)O.O=P(O)(O)O

Molecular Formula

C26H32F3N3O11P2

Molecular Weight

681.49

Precautions

H360

References & Citations

[1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1 (3) :130-4.|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.