Proflavine (hemisulfate)
Product Specifications
UNSPSC Description
Proflavine hemisulfate, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine hemisulfate behaves as a pore blocker for Kir3.2. Proflavine hemisulfate is a potential lead compound for Kir3.2-associated neurological diseases[2].
Target Antigen
Autophagy; Bacterial; Potassium Channel
Type
Dye Reagents
Related Pathways
Anti-infection;Autophagy;Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Proflavine-hemisulfate.html
Purity
98.45
Solubility
DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : ≥ 5 mg/mL
Smiles
NC1=CC2=NC3=CC(N)=CC=C3C=C2C=C1.[0.5H2SO4]
Molecular Weight
258.28
References & Citations
[1]Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.|[2]Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.|[3]Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0883/Proflavine-hemisulfate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0883/Proflavine-hemisulfate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1811-28-5
Available Sizes
Curated Selection
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