Mps1-IN-10
Product Specifications
UNSPSC Description
Mps1-IN-10 (Compound 9) is an inhibitor for Mps1 with an IC50 of 6.4 nM. Mps1-IN-10 inhibits the proliferation of cancer cell MDA-MB-231 with a GI50 of 11 nM. Mps1-IN-10 exhibits anti-tumor efficacy in mice MDA-MB-231 xenograft models[1].
Target Antigen
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mps1-in-10.html
Smiles
N#CC1=CNC2=NC(NC3=CC=C(N4C(CCC4)=O)C=C3OC)=NC(NC5CCCCC5)=C21
Molecular Weight
445.52
References & Citations
[1]Lee Y, et al., X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J Med Chem. 2021 May 27;64(10):6985-6995.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-165421/Mps1-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-165421/
Clinical Information
No Development Reported
CAS Number
2489220-49-5
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