ENTK (light chain, Cleaved-Ile785) rabbit pAb

Catalytic activity:Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond., disease:Defects in PRSS7 are a cause of enterokinase deficiency [MIM:226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive., function:Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A) . It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases., PTM:The chains are derived from a single precursor that is cleaved by a trypsin-like protease., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 MAM domain., similarity:Contains 1 peptidase S1 domain., similarity:Contains 1 SEA domain., similarity:Contains 1 SRCR domain., similarity:Contains 2 CUB domains., similarity:Contains 2 LDL-receptor class A domains., subunit:Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond., tissue specificity:Intestinal brush border.

Enteropeptidase (EC 3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]