Cdk4 Monoclonal Antibody
Product Specifications
Background
Cyclin dependent kinase 4 (CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Product Name Alternative
CDK4; Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3
Gene ID
1019
Swiss Prot
P11802
Cross Reactivity
Human; Mouse; Rat; Dog; Pig
Clonality
Monoclonal
Source
Mouse
Applications
WB
Dilution
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Buffer
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Storage Conditions
-20°C/1 year
Available Sizes
Curated Selection
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