RCC1 Antibody

Disease:Patients with Raynaud disease produce antibodies that bind to RCC1. Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Contains 7 RCC1 repeats. subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.