EWS Antibody
Product Specifications
Background
The Ewing Sarcoma Breakpoint Region 1 (EWSR1) gene encodes the EWS protein, which along with FUS and TAF15 comprises the FET family of RNA-binding proteins. EWS is primarily expressed in the nucleus, but has also been found in the cytoplasm of secretory cell types (Andersson et al., 2008) . Defects of EWSR1 are known to cause Ewing sarcoma and have been implicated in amyotrophic lateral sclerosis (ALS) (Svetoni et al., 2016) . Recently, EWS has been shown to directly interact with oncogenic ETS transcription factors in the promotion of prostate cancer (Kedage et al., 2016) .
Synonyms
4 Ewing sarcoma breakpoint region 1 protein antibody, Ewing sarcoma breakpoint region 1 antibody, Ewing sarcoma breakpoint region 1 protein antibody, Ewings sarcoma EWS Fli1 type 1 oncogene antibody, EWS antibody, EWS oncogene antibody, EWS RNA binding protein 1 antibody, EWS_HUMAN antibody, EWSR 1 antibody, Ewsr1 antibody, EWSR1 protein antibody, RNA binding protein EWS antibody, RNA-binding protein EWS antibody
Gene ID
2130
Swiss Prot
Q01844
Host
Mouse
Cross Reactivity
Human, Mouse, Rat, Dog
Target
EWS
Clonality
Monoclonal
Isotype
IgG2b
Clone
5H7
Conjugation
Unconjugated
Source
Full length recombinant human EWS expressed in and purified from E. coli.
Applications
WB, IHC
Purification
Purified by Protein G.
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IHC ()
Buffer
PBS + 50% glycerol and 5 mm NaN3
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Product Datasheet
https://www.biossantibodies.com/datasheets/bsm-70085M
Specificity
Specific for endogenous levels of the ~85 kDa EWS protein.
Gene ID URL
2130
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