KLF4 (5A1) Monoclonal Antibody

Product Specifications

Background

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Synonyms

EZF; GKLF; Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor; KLF4

Gene ID

9314

Swiss Prot

O43474

Host

Mouse

Target

KLF4

Clonality

Monoclonal

Isotype

IgG1

Clone

5A1

Conjugation

Unconjugated

Source

KLF4 recombinant protein is used to produce this monoclonal antibody.

Applications

WB, IF (ICC)

Purification

Purified mouse monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.