FOX C2 Polyclonal Antibody

FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3) . FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4) . Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4) . FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3) . FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5) . Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3) . FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2) .

Drosphilia Forkhead Homolog Like 14; Drosphilia Forkhead Homolog Like 14; FKHL 14; FKHL 14; FKHL14; Forkhead Box C2; Forkhead Box C2; Forkhead box protein C2; Forkhead related protein FKHL14; Forkhead-related protein FKHL14; FOX C2; Foxc2; FOXC2_HUMAN; LD; Mesenchyme fork head protein 1; Mesenchyme Forkhead 1; Mesenchyme Forkhead 1; MFH 1; MFH 1; MFH 1 protein; MFH-1 protein; MFH1; Transcription factor FKH 14; Transcription factor FKH-14.