Rad23 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated

The RAD23 gene of Saccharomyces cerevisiae is required for excision-repair of UV damaged DNA (1) . RAD23 resembles the other DNA repair genes, RAD2, RAD6, RAD7, RAD18, and RAD54, all of which also exhibit increased transcription in response to DNA damage and during meiosis (2) . RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function (3) . RAD23 bears a ubiquitin-like domain at its amino terminus and this ubiquitin-like domain affects protein function in a nonproteolytic manner (3) . Rad23 is a highly conserved protein involved in nucleotide excision repair (NER) that associates with the proteasome via its amino-terminus (4) . Its carboxy-terminal ubiquitin-associated domain is evolutionarily conserved from yeast to humans (4) . In addition to a role in DNA repair events in yeast, several lines of evidence indicate that the Rad23 protein may regulate the activity of the 26 S proteasome (5) .