Caspase 2 Polyclonal Antibody
Product Specifications
Background
Caspase 2 has a positive and a negative role in the regulation of the apoptotic process. Overexpression of the full length Caspase 2 (Nedd2/Ich1) mRNA in some cell types results in apoptosis, whereas overexpression of an alternative Caspase 2 splice variant suppresses apoptosis induced by serum withdrawal. Caspase 2 may be activated in vitro by Caspase 1, Caspase 3 and the neutral serine protease granzyme B which is stored in the specialized lytic granules of cytotoxic lymphocytes.
Synonyms
Apoptosis related cysteine peptidase; CASP 2; Casp 2L Pro; CASP2; Caspase 2 apoptosis related cysteine protease; Caspase2; Developmentally down regulated 2; ICH 1; ICH 1 protease; ICH 1L; ICH 1L/1S; ICH1; ICH1 protease; ICH1L; ICH1L/1S; NEDD 2; NEDD2; NEDD2 apoptosis regulatory gene; Neural precursor cell expressed; Neural precursor cell expressed developmentally down regulated 2.
Gene ID
835
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Rat
Immunogen
251-350/452
Target
Caspase 2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Caspase 2
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
835
Predicted Cross Reactivity
Human, Mouse, Cow, Pig, Horse, Rabbit
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6465068-02 5x 0.2 mL
Bmf, BH3 Domain (Bcl-2 Modifying Factor) (Azide free) (HRP)
Ask
View Details ![RAB21 Mouse Monoclonal Antibody [Clone ID: OTI4A6]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
