CBX3 Polyclonal Antibody

Product Specifications

Background

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Synonyms

Chromobox protein homolog 3, CBX3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein

Gene ID

11335

Swiss Prot

Q13185

Host

Rabbit

Cross Reactivity

Human

Target

CBX3

Clonality

Polyclonal

Conjugation

Unconjugated

Source

Polyclonal antibody raised in rabbit against human CBX3 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively