Phospho-Desmin (Thr16) Polyclonal Antibody, AbBy Fluor™ 405 Conjugated
Product Specifications
Background
Filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM) . CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM) . Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I) . CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin are useful in identification of tumours of myogenic origin.
Synonyms
Desmin phospho Thr17; Desmin phospho Thr17; CMD1I; CSM1; CSM2; DES; FLJ12025; FLJ39719; FLJ41013; FLJ41793; Intermediate filament protein; OTTHUMP00000064865; DESM_HUMAN
Gene ID
1674
Modification Site
Thr17
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Desmin (Thr16)
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 405
Source
KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr17
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
401nm/421nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-5301R-BF405
Gene ID URL
1674
Predicted Cross Reactivity
Cow, Chicken
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
