PIWIL1 Polyclonal Antibody

Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability.

Polyclonal antibody raised in rabbit against human PIWIL1 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively

Polyclonal antibody raised in rabbit against human PIWIL1 (piwi-like 1) using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively