BMI1 Polyclonal Antibody

Product Specifications

Background

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Synonyms

PCGF4, RNF51, FLVI2

Gene ID

648

Swiss Prot

P35226

Host

Rabbit

Cross Reactivity

Mouse

Target

BMI1

Clonality

Polyclonal

Conjugation

Unconjugated

Source

Polyclonal antibody raised in rabbit against mouse BMI1 using two KLH-conjugated synthetic peptides containing a sequence from the central and the C-terminal region of the protein, respectively