DBC2 Polyclonal Antibody
Product Specifications
Background
DBC2 is a member of the recently identified RhoBTB family, which is part of the Rho GTPase family. DBC2 has been implicated as a tumor suppressor in breast and lung cancer. Studies have shown that DBC2 binds to the ubiquitin ligase scaffold Cul3, and that Cul3 regulates DBC2 protein levels by ubiquitinating DBC2 directly, leading to its degradation by the proteasome.
Synonyms
DBC2; Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein; p83; RHOBTB2; KIAA0717
Gene ID
23221
Swiss Prot
Q9BYZ6
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
631-727/727
Target
DBC2
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human DBC2
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
23221
Predicted Cross Reactivity
Mouse, Rat, Cow, Pig, Horse
Curated Selection
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