Histone H3 (acetyl K9) Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms
H3F3; H3.3A; Histone H3.3; H3F3A; PP781
Gene ID
3020
Swiss Prot
P84243
Modification Site
Acetyl K9
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Histone H3 acetyl K9
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy7
Source
KLH conjugated synthetic acetylpeptide derived from human Histone H3 around acetylation site of Lys9
Applications
WB, FCM
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Acetylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-3776R-PE-Cy7
Specificity
This acetylation site is homologous across the species listed.
Gene ID URL
3020
Predicted Cross Reactivity
Cow, Pig, Rabbit, Fruit Fly
Curated Selection
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