ID2 Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Synonyms
GIG8; ID2A; ID2H; bHLHb26; DNA-binding protein inhibitor ID-2; Class B basic helix-loop-helix protein 26; Inhibitor of DNA binding 2; Inhibitor of differentiation 2; ID2
Gene ID
3398
Swiss Prot
Q02363
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Rat
Immunogen
31-134/134
Target
ID2
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human GIG8/ID2
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-3515R-APC-Cy7
Specificity
Due to the similarity of this protein with ID1, this antibody has a chance to have light cross-reactivity with ID1 due to a 77% sequence similarity in the range of our immunogen.
Gene ID URL
3398
Predicted Cross Reactivity
Mouse, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
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