Isoviolanthin

Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma[1][2][3].

Product Specifications

CAS Number

[40788-84-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Akt; Histone Demethylase; MMP; mTOR; PI3K; TGF-beta/Smad

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/isoviolanthin.html

Purity

99.66

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC1=C([C@H]2[C@@H]([C@@H]([C@@H](O)[C@H](C)O2)O)O)C(O)=C(C(C=C(C3=CC=C(O)C=C3)O4)=O)C4=C1[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO

Molecular Formula

C27H30O14

Molecular Weight

578.52

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Xing S, et al. Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. Int J Mol Sci. 2018 May 23;19 (6) .|[2]Wang J, et al. Research on the resistance of isoviolanthin to hydrogen peroxide-triggered injury of skin keratinocytes based on Transcriptome sequencing and molecular docking. Medicine (Baltimore) . 2023 Nov 24;102 (47) :e36119.|[3]Su Y, et al. Isoviolanthin promotes Schwann cells activity in peripheral nerve regeneration via Fhl3-mediated epithelial-mesenchymal transition-like process: An in vitro study. Heliyon. 2024 Dec 12;11 (1) :e41087.