Ezetimibe

Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Product Specifications

CAS Number

[163222-33-1]

Product Name Alternative

SCH 58235

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

Autophagy; Keap1-Nrf2

Type

Reference compound

Related Pathways

Autophagy; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Ezetimibe.html

Purity

99.95

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O

Molecular Formula

C24H21F2NO3

Molecular Weight

409.43

Precautions

H302, H319, H372, H410

References & Citations

[1]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.|[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21 (25) :7754-63.