5HT2A Receptor Polyclonal Antibody, APC Conjugated

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1- (2,5-dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538) . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538) . Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538) . Affects neural activity, perception, cognition and mood (PubMed:18297054) . Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.