Pralidoxime (iodide)

Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE) . Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].

Product Specifications

CAS Number

[94-63-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pralidoxime-iodide.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C[N+]1=CC=CC=C1/C=N/O.[I-]

Molecular Formula

C7H9IN2O

Molecular Weight

264.06

Precautions

H302

References & Citations

[1]Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259 (Pt B) :133‐141.|[2]Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368 (9553) :2110‐2111.|[3]Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46 (2) :131‐138.