BIRC6 Polyclonal Antibody
Product Specifications
Background
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Synonyms
BRUCE; APOLLON; Baculoviral IAP repeat-containing protein 6; BIR repeat-containing ubiquitin-conjugating enzyme; Ubiquitin-conjugating BIR domain enzyme apollon; BIRC6; KIAA1289
Gene ID
57448
Swiss Prot
Q9NR09
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human
Immunogen
4701-4857/4857
Target
BIRC6
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Apollon
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
57448
Predicted Cross Reactivity
Mouse, Rat, Cow, Pig, Horse, Rabbit
Curated Selection
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