GGA1 Polyclonal Antibody, AbBy Fluor™ 405 Conjugated

The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?) . Members of the GGA family, GGA1, GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4) . GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5) . The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3) . GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2) . The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6) . The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1) .

4930406E12Rik; ADP ribosylation factor binding protein 1; ADP ribosylation factor binding protein GGA1; ADP-ribosylation factor-binding protein GGA1; ARF binding protein 1; ARF-binding protein 1; Gamma adaptin related protein 1; gamma ear-containing; Gamma-adaptin-related protein 1; GGA 1; GGA1; GGA1 protein; GGA1_HUMAN; Golgi associated gamma adaptin ear containing ARF; Golgi associated gamma adaptin ear containing ARF binding protein 1; Golgi localized gamma ear containing ARF binding protein 1; Golgi-localized; OTTHUMP00000028975; OTTHUMP00000042200.