Flecainide (acetate)

Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

Product Specifications

CAS Number

[54143-56-5]

Product Name Alternative

R-818

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H360

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/flecainide-acetate.html

Purity

99.35

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=C(NCC1NCCCC1)C2=CC(OCC(F)(F)F)=CC=C2OCC(F)(F)F.CC(O)=O

Molecular Formula

C19H24F6N2O5

Molecular Weight

474.39

Precautions

H302, H315, H319, H335, H360

References & Citations

[1]Yamashita T, Nakajima T, Hamada E,  Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274 (1) :315-21.|[2]Desaphy JF, De Luca A, Didonna MP, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554 (Pt 2) :321-34.|[3]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65 (2) :168-71.