MAGI1 Polyclonal Antibody

The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.

AIP 3; AIP3; Atrophin 1 interacting protein 3; atrophin-1 interacting protein 3; BAI associated protein 2; BAI1 associated protein 1; BAI1-associated protein 1; BAIAP 1; BAIAP1; BAP 1; BAP1; BAP2; Brain specific angiogenesis inhibitor 1 associated protein 2; Fas ligand associated factor 3; FLAF3; Gukmi1; Insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; IRS 58; IRSP53; IRSp53/58; MAGI 1; MAGI-1; MAGI1c; Membrane associated guanylate kinase inverted 1; membrane associated guanylate kinase inverted-1; membrane associated guanylate kinase WW and PDZ domain containing 1; Protein BAP2; TNRC 19; TNRC19; Trinucleotide repeat containing gene 19; Trinucleotide repeat containing gene 19 protein; trinucleotide repeat-containing gene 19; WW domain containing protein 3; WW domain-containing protein 3; WWP 3; WWP3.