CRIPT Polyclonal Antibody, APC-Cy7 Conjugated
Product Specifications
Background
The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. These proteins are physically and functionally linked to cytoskeletal and/or signaling proteins. CRIPT (for cysteine-rich interactor of PDZ three), a novel postsynaptic protein, binds specifically to the PDZ3 domain of PSD-95/SAP 90. CRIPT induces the recruitment of PSD-95/SAP 90 to microtubules, and it has been shown to bind directly to microtubules, indicating that it may be responsible for cytoskeletal anchoring of PSD-95/SAP 90. CRIPT is widely expressed outside of the brain and is highly conserved from animals to plants suggesting a wider role in regulating cytoskeleton-membrane associations.
Synonyms
CRIPT; CRIPT_HUMAN; Cysteine rich interactor of PDZ3; Cysteine rich PDZ binding protein; Cysteine-rich interactor of PDZ three; Cysteine-rich interactor of PDZ3; Cysteine-rich PDZ-binding protein; HSPC139; HSPC139 protein; Hypothetical protein CRIPT; Postsynaptic protein CRIPT.
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Immunogen
21-80/101
Target
CRIPT
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy7
Source
KLH conjugated synthetic peptide derived from human CRIPT
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Mouse, Rat, Cow, Pig, Chicken
Curated Selection
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